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Tramadol hydrochloride is a synthetic opioid analgesic that acts centrally. It is used to treat moderate to severe pain. It acts by binding to mu-opioid receptors in the central nervous system, blocking serotonin and norepinephrine reuptake and so modulating pain perception. It works similarly to codeine but is thought to have a reduced potential for misuse than other opioids.
Tramadol is available in a variety of forms, including immediate-release tablets, extended-release tablets, and capsules. Adults’ normal initial dose ranges from 25 mg to 50 mg every four to six hours as needed for pain management. Adults are normally advised to take no more than 400 mg per day.